X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a urea based inhibitor PSMA 1027

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a urea based inhibitor PSMA 1027 Descriptor: (2~{S})-2-[[(2~{S})-6-[[(2~{S})-2-[[4-[[[(2~{S})-2-[[(2~{R})-2-[(6-fluoranylpyridin-3-yl)carbonylamino]-3-sulfo-propanoyl]amino]-3-sulfo-propanoyl]amino]methyl]phenyl]carbonylamino]-3-naphthalen-2-yl-propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Novakova, Z, Barinka, C, Motlova, L. Deposit date: 2017-06-02 Release date: 2018-06-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a urea based inhibitor PSMA 1027 To Be Published人类谷氨酸羧肽酶II（human glutamate carboxypeptidase II, GCPII）与尿素类抑制剂PSMA 1027结合的X射线晶体结构。结构描述：(2S)-2-[[(2S)-6-[[(2S)-2-[[4-[[[(2S)-2-[[(2R)-2-[(6-氟吡啶-3-基)羰基氨基]-3-磺酰基丙酰基]氨基]-3-磺酰基丙酰基]氨基]甲基]苯基]羰基氨基]-3-萘-2-基丙酰基]氨基]-1-羟基-1-氧代己-2-基]氨基甲酰氨基]戊二酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Novakova Z、Barinka C、Motlova L。沉积日期：2017年6月2日；发布日期：2018年6月13日；最后修改日期：2024年11月6日。实验方法：X射线衍射（1.53埃）。引用文献：人类谷氨酸羧肽酶II（GCPII）与尿素类抑制剂PSMA 1027结合的X射线晶体结构【待发表】