A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity

Community Contributed publication dataset from Manuel Garber and John E. Harris of the University of Massachusetts Chan Medical School Vitiligo Center of Research Translation (V-CoRT). Using a variety of investigational methods the authors examined in vivo and in vitro samples to investigate an interferon-I (IFN-I)-amplified skin pathology and identified MMP9+ CD14+ myeloid cells as central effectors of photosensitivity in both cutaneous lupus erythematosus and dermatomyositis.