Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [RNA-seq]. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [RNA-seq]

We used a CRISPR-based screening approach to identify functional vulnerabilities in pediatric sarcoma cell types, identifying BRD9 as an important dependency in synovial sarcoma cells. Overall design: RNA-seq in synovial cells treated with dBRD9A or DMSO for 6hrs, or the same cells expressing control (Renilla) or SS18-SSX1 specific shRNAs.