去甲肾上腺素介导的觉醒波动驱动倒U形功能连接动态性

Arousal dynamically shapes brain function and behavioral performance, as posited by the Yerkes-Dodson law. Yet, functional network substrates underlying this inverted U-shaped pattern remain unknown. Here, by integrating fMRI with simultaneous electroencephalography (EEG) across humans and awake mice, we found arousal modulated inverted U-shaped global functional connectivity (FC) dynamics, peaking at middle arousal level. Such inverted U-shaped FC exhibited significant correlation with arousal modulated behavioral performance, recapitulating the Yerkes-Dodson framework at the functional network level. Further combining invasive multimodal neural recording and manipulations of locus coeruleus-norepinephrine (LC-NE) neurons with awake mouse EEG-fMRI, we revealed the causal contribution of LC-NE system to arousal modulated FC dynamics, in which the inverted U-shaped pattern was dependent on the baseline arousal level. To summarize, we uncovered the functional network basis of the Yerkes-Dodson law, which was driven by the NE-mediated arousal fluctuations.