Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCINE, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Ota, T, Senoo, A, Ito, S, Ueno, G, Nagatoishi, S, Tsumoto, K, Sando, S. Deposit date: 2020-03-11 Release date: 2021-01-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. Iscience, 24, 2021人类丝氨酸羟甲基转移酶1与磷酸吡哆醛5'-磷酸（Pyridoxal 5'-phosphate，PLP）及甘氨脱氧胆酸形成的共晶结构。结构描述符：(3α,5β,12α)-3,12-二羟基胆烷-24-羧酸、甘氨酸、磷酸吡哆醛-5'-磷酸……作者：Ota T、Senoo A、Ito S、Ueno G、Nagatoishi S、Tsumoto K、Sando S。提交日期：2020-03-11，发布日期：2021-01-20，最后修改日期：2023-11-29。实验方法：X射线衍射（3.1 Å）。引用文献：《次级胆汁酸结合物选择性抑制人类丝氨酸羟甲基转移酶的结构基础》，《Iscience》，24卷，2021年。