Comparison of the Canonical Correlation Analysis and Forward Selection of the biomarkers.

By applying CCA for all possible -combinations , the subset of biomarkers with the highest correlation with the sepsis score is determined. The ‘Enter’ column indicates which biomarker is added to achieve the highest correlation at each . The ‘Leave’ column indicates which biomarker is eliminated from the combination at that particular . A biomarker will stay in the combination until it occurs in ‘Leave’ column. For instance, for the -combination, the most correlated biomarkers include Bands, Plt, CD64, Segs, and WBC. Hgb, which was present in the -combination, is replaced by Segs and WBC at level . The ‘Forward Selection’ column is the biomarker selected by the forward selection method when applied one biomarker at a time.