REVMATOID ARTRITLI BEMORLARDA GIPERURIKEMIYANING KLINIK VA PATOGENETIK AHAMIYATI

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease characterized by destructive joint damage and the involvement of multiple organs. In recent years, the prevalence of hyperuricemia (elevated levels of uric acid in the blood) in RA patients and its impact on the disease course are being studied as a significant scientific issue. The purpose of this article is to systematically analyze the pathogenetic mechanisms, clinical significance, and association of hyperuricemia with comorbid conditions in patients with RA. A literature review indicates that hyperuricemia in RA patients is closely associated with inflammatory activity, cardiovascular complications, and renal dysfunction. While uric acid has antioxidant properties on the one hand, at high concentrations it manifests as a pro-inflammatory mediator.