Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878

Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: West, B.R, Moyer, C.L, King, L.B, Fusco, M.L, Milligan, J.C, Hui, S, Saphire, E.O. Deposit date: 2018-08-02 Release date: 2018-09-19 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (4.25 Å) Cite: Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. MBio, 9, 2018埃博拉病毒（Ebola virus, EBOV）GPcl蛋白与泛埃博拉病毒单克隆抗体（monoclonal antibody, mAb）ADI-15878的复合物结构 描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：West, B.R、Moyer, C.L、King, L.B、Fusco, M.L、Milligan, J.C、Hui, S、Saphire, E.O. 提交日期：2018-08-02 发布日期：2018-09-19 最后修改日期：2024-10-16 实验方法：X射线衍射法（X-RAY DIFFRACTION），分辨率4.25埃（Å） 引用文献：《人源抗体靶向保守隐蔽表位实现泛埃博拉病毒中和的结构基础》，MBio，第9卷，2018年