Transcriptomic profiles of ivosidenib-sensitive and ivosidenib-resistant IDH1-mutated murine bone marrow cells

To study the mechanism of resistance to ivosidenib, we developed a model of acquired drug resistance by treating ivosidenib-sensitive OCI-mIDH1/N cells continuously with ivosidenib in culture for a period of 2 months followed by a drug washout period. The resulting cell population (OCI-mIDH1/N-R cells) failed to differentiate upon ivosidenib treatment. We then performed RNA sequencing (RNA-seq) analysis of OCI-mIDH1/N and OCI-mIDH1/N-R cells. Comparative gene expression profiling analysis of RNA-seq data for ivosidenib-sensitive and ivosidenib-resistant IDH1-mutated murine bone marrow cells.