Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling. Homo sapiens

EMP1 is a family member of epithelial membrane proteins (EMP1 EMP3). However, how EMP1 relates to urothelial Bca is unclear. we demostrated that loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis.To identify the mechanism by which EMP1 influences cell motility and redox homeostasis, we performed RNA seq to assay the transcriptomes of EMP1 knockdown 5637 cells.