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Microglia control the formation of brain small vessel calcfication via TREM2

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135449
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The role of microglia in the formation of brain capillary calcification was investigated in a platelet-derived-growth factor B (PDGFB) hypomorph - Pdgfb ret/ret mouse model of human primary familial brain calcification. RNA-seq was performed on brain tissue developing vessel-associated calcifications (n=4 thalamus) and on brain tissue lacking calcifications (n=4 cortex) of Pdgfb ret/ret animals. Control animals (Pdgfb wt/ret) do not develop calcifications in any of the analyzed regions (n=4 thalamus and n=4 cortex).
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2021-03-16
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