Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor Descriptor: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-7-methyl-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... Authors: Mohr, C. Deposit date: 2019-06-08 Release date: 2019-08-28 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
创建时间：
2019-06-08
