Coevolved residues of dimer interface of OmpR/PhoB family calculated by GREMLIN: Listed are the interacting residues with their respective numberings and topology.

Italicized pairs indicate coevolved inter-monomeric contacts of RegX3 but intra-monomeric contacts in other OmpR/PhoB family members. Bold representation highlights those dimeric interactions conserved in all OmpR/PhoB family members. Contact pair with asterisk symbol satisfies all available active RR structures in this family but not RegX3.