fhod3 deficiency leads to cardiomyopathy in hESC-CMs
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下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP615437
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资源简介：
we generated a FHOD3 knockout (FHOD3-/-) human embryonic stem cell (hESC) cell line (H9) by CRISPR/Cas9 system and differentiate it into cardiomyocytes to elucidate the mechanism of cardiomyopathy and HF caused by FHOD3 deficiency. Our study found that FHOD3-deficient hPSC-CMs presented sarcomere disorganization and degradation. In addtion, impaired calcium homeostasis aggravated the pathogenesis of myocardial dysfunction and HF.
创建时间：
2025-09-02
