Distances between the Zn atom and its coordinating atoms^a.

aMean values and standard deviations are in Å. bDistance between Zn and the ligand backbone carbonyl oxygen of the scissile bond. cMean values and standard deviations obtained by averaging over 9 PDB structures of aminopeptidase N: P. falciparum (3EBH, 3EBI, 3EBG; [15]), E. coli (2ZXG; [24]), E. coli (2HPT, 2HPO; [17]), E. coli (2DQM, 2DQ6; [16]), N. meningitidis (2GTQ; [18]). The protein atom-Zn distances are the means of 9 measurements, while the water molecule distance is the mean distance measured from 4 unliganded structures. dFrom PfA-M1 simulations, distances sampled every 50 ps over the 75 ns simulations.