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Msi1 integrates APC loss and mTORC1 activation to promote intestinal stem cell transformation

ChEBI2015-10-22 更新2026-07-12 收录

肿瘤发生机制

干细胞转化分子通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-54598 数据链接链接失效反馈

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Msi1 integrates APC loss and mTORC1 activation to promote intestinal stem cell transformation

应用场景：

创建时间：

2015-10-22

肿瘤发生机制

细胞衰老调控

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results also show that SIX1 acts as a repressor of cell senescence, an antiproliferative response wit

NIAID Data Ecosystem110

Transcriptome changes following loss of Apc in the intestine. Mus musculus

肿瘤发生机制

Wnt信号通路靶基因

Nearly all colorectal cancers have dysregulated Wnt signalling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the ke

NIAID Data Ecosystem40

Gene expression profiling of preneoplastic Lgr5-creERT2/PIK3CAH1047R mammary subsets

肿瘤发生机制

基因突变效应分析

This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from Lgr5-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from

NIAID Data Ecosystem30

p53 amyloid formation induced cellular transformation and tumor formation in xenograft model

p53

肿瘤发生机制

p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.

NIAID Data Ecosystem50

Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

黏液样脂肪肉瘤

肿瘤发生机制

Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a ha

NIAID Data Ecosystem40

Msi1 integrates APC loss and mTORC1 activation to promote intestinal stem cell transformation

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