The gene regulation landscape of MTAP in lung adenocarcinoma

MTAP is an enzyme and found deleted in various cancers, but its role in lung adenoacrcinoma is still unclear. This study sought to investigate the effects of MTAP on the biological behavior and global gene expression profiles in lung adenocacinoma cells. We used expression microarrays to identify the global gene alterations in lung adenocacinoma cell line, CL1-5 cells after ectopically expressing V5-tagged MTAP gene. Ectopically expressing V5-tagged MTAP gene and control vector (pcDNA3.1/V5-His-TOPO) in low MTAP-expressing lung cancer cell line, CL1-5.