Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting synovial joints and leading to cartilage damage and bone loss. This destruction is promoted by activated fibroblast-like synov
Background: The driving force behind osteoarthritis (OA) pathogenesis is an anabolic-catabolic (a/c) imbalance. Melatonin (MT) is a key player in maintaining a/c stability and mitigates OA pathogenesi
Objective: To explore the role of bone marrow adipocytes (BMAds) in osteoarthritis (OA). Methods: Male and female C57BL/6 mice (n=4/group) underwent meniscectomy (MNX) or SHAM surgery. OA was determin
To investigate effects of excessive mechanical loading on chondrocytes. Primary chondrocytes were isolated from 6-day-old C57BL/6J mice, and were subjected to cyclic tensile strain (0.5 Hz, 10% elonga
Datasets. Datasets used for quantification. In figures where data are quantified, the datasets are included in tabs of this Excel file labeled by figure number or data described. The “Fig. 2” tab incl
