Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor

Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor Descriptor: 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one, GLYCEROL, SULFATE ION, ... Authors: Harrison, T, Gavory, G, O'Dowd, C, Helm, M, Flasz, J, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H, Feutron-Burton, S, Rountree, J.S.S. Deposit date: 2017-12-01 Release date: 2018-04-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors. ACS Med Chem Lett, 9, 2018泛素特异性蛋白酶7（USP7）与4-羟基哌啶类抑制剂的复合物晶体结构 描述符：3-[[4-羟基-1-[(3R)-3-苯基丁酰基]哌啶-4-基]甲基]-6-(2-吡咯烷-1-基乙基氨基)嘧啶-4-酮、甘油（GLYCEROL）、硫酸根离子（SULFATE ION）等 作者：Harrison, T、Gavory, G、O'Dowd, C、Helm, M、Flasz, J、Dossang, A、Hughes, C、Cassidy, E、McClelland, K、Odrzywol, E、Page, N、Barker, O、Miel, H、Feutron-Burton, S、Rountree, J.S.S. 沉积日期：2017-12-01 发布日期：2018-04-11 最后修改日期：2024-05-08 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.16埃（Å） 引用：《基于嘧啶酮类USP7抑制剂的发现与结构导向开发》（Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors），《ACS药物化学通讯》（ACS Med Chem Lett），第9卷，2018年