Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom
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Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... Authors: Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. Deposit date: 2022-06-22 Release date: 2023-04-26 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
分辨率为2.4埃的、在氯化钠溶液中处于向内闭合构象的结合γ-氨基丁酸(GABA)的人源γ-氨基丁酸转运蛋白GAT1的冷冻电镜(Cryo-EM)结构 描述符:2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、氯离子、γ-氨基丁酸…… 作者:Zhu A、Huang J、Kong F、Tan J、Lei J、Yuan Y、Yan C 沉积日期:2022-06-22 发布日期:2023-04-26 最后修改日期:2025-06-18 实验方法:电子显微镜(2.4 Å) 引用文献:人源γ-氨基丁酸转运蛋白GAT1的底物识别与转运分子机制。《自然·结构与分子生物学》(Nat.Struct.Mol.Biol.),30卷,2023年



