The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simulta

NIAID Data Ecosystem30

RNAseq1

转录组测序

原发性硬化性胆管炎机制

Transcriptome sequencing for PSC samples.

NIAID Data Ecosystem20

Intestinal expression of ASBT determines the sclerosing cholangitis phenotype.

原发性硬化性胆管炎机制

胆汁酸代谢相关肝损伤

Purpose: Determine the impact of ASBT genotype on the onset and progression of liver disease, using RNA-sequencing to characterize the transcriptome of ASBT wildtype and knockout mice. We assess alter

NIAID Data Ecosystem30

All 301 proteins with two or more unique peptides quantified in bile samples from PSC patients and non-PSC controls.

生物标志物发现

原发性硬化性胆管炎机制

Proteins that passed the cutoff of a Mann-Whitney p-value of less than 0.05 are shaded in blue. Significantly different proteins that also have a fold change of >2 are further given in bold. (XLSX)

Figshare2022-08-25 更新30

EpiPSC2 medication and disease stage file_SEP2023.sav

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