Effect of Liver-specific SelO Knockout on the Liver Transcriptome of Mice on a Normal Diet

This study investigates the role of SelO in liver metabolism. RNA sequencing analysis of mouse liver tissues revealed significantly differentially expressed genes enriched in pathways related to fatty acid beta-oxidation and NAD-related metabolic processes. Our cell biology and biochemistry experiments suggest that SelO is involved in lipid metabolism. These findings indicate that the knockout of SelO leads to transcriptomic changes that align with increased lipid oxidation Overall design: RNA-seq using total RNA. Three knockout samples, three control samples. Comparative gene expression profiling analysis of RNA-seq for liver tissues from control mice and knockout mice.