I-mfa, mesangial cell TRPC1 channel, and regulation of glomerular filtration rate

Glomerular filtration rate (GFR) in I-mfa knockout (KO) mice and wild type (WT) mice; GFR in I-mfa+/+ mice with and without knockdown of I-mfa in MCs; Contractile function of human mesangial cells with and without overexpression or knockdown of I-mfa; Contractile function of primary mouse mesangial cells isolated from I-mfa WT and KO mice; TRPC1 and TRPC6 protein abundance in primary MMCs with and without I-mfa deletion; and Ca2+ entry response in HMCs with and without knockdown of I-mfa.