Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1)

Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab (focused refinement of the S2-76E1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of 76E1 Fab, ... Authors: Liu, Z.M, Bao, Z.H, Sun, X.Y, Sun, L. Deposit date: 2025-01-05 Release date: 2026-04-22 Last modified: 2026-05-20 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Nature, 2026