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Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

NIAID Data Ecosystem2026-03-12 收录

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潘氏细胞特性

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA661575 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-09-04

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分子生物学

Proposed model for the mechanism of colon cancer metastasis to the liver involves exporting miR-193a via exosomes sorted by major vault protein (MVP). In pre-metastatic cells miR-193a suppresses mous

wikipathways.github.io80

Mouse tumors were induced by conditional alleles of the WNT, EGFR, TGF-beta and p53 pathways in intestinal stem cells of adult mice. Multiple primary tumours or metastases were cultured in 3D in conditions equivalent to those established for human CRC organoids. TGF-beta drives immune evasion in genetically reconstituted colon cancer metastasis

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免疫治疗

Most colorectal cancer (CRC) patients die as a result of metastasis. Neither conventional chemotherapy nor current targeted therapies offer long-lasting benefits once the disease has spread to distant

NIAID Data Ecosystem50

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

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基因表达预后分类器

Background and Aim: Fra-1 (Fos-related antigen-1) is a member of the AP1 (activator protein-1) family of transcription factors. We have recently shown that Fra-1 is necessary for breast cancer cells t

NIAID Data Ecosystem30

Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG III. Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG III

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VSIG蛋白

Our study prompeted us to assign, through spiked single cell RNAseq, metastatic function to transcriptomic cluster of colon cancer cells. Interactions between clones also uncover a restrictive anti me

NIAID Data Ecosystem60

POG_patient_25742 - samples

癌症基因组数据

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Genome and transcriptome sequence data from a metastatic colon cancer patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) studyEGA dataset EGAD00001002977

NIAID Data Ecosystem30

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

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