A Concise Synthetic Approach to the Sorbicillactones: Total Synthesis of Sorbicillactone A and 9-<i>epi</i>-Sorbicillactone A
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A concise (12 step) total synthesis of sorbicillactone A and 9-epi-sorbicillactone A is reported. Unlike typical routes to the sorbicillinoids, this strategy does not start from sorbicillin and allows for the production of the bicyclic core on a multigram scale. The intramolecular conjugate addition of a tethered malonate serves as an effective means of introducing the lactone ring and provides a synthetic handle for installing the amide nitrogen.
创建时间：
2011-09-02
