Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a

Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine, CALCIUM ION, ... Authors: Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. Deposit date: 2020-09-15 Release date: 2020-12-09 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020人源TRPV6与(4-苯基环己基)哌嗪类抑制剂cis-22a复合物的冷冻电镜（Cryo-EM）结构。组分描述：1,2-二油酰基-sn-甘油-3-磷酸胆碱、1-[顺式-4-(3-甲基苯基)环己基]-4-(吡啶-3-基)哌嗪、钙离子……。作者：Neuberger, A、Nadezhdin, K.D、Singh, A.K、Sobolevsky, A.I.。存档日期：2020-09-15；发布日期：2020-12-09；最后修改日期：2025-05-21。实验方法：电子显微镜（分辨率3.1 Å）。引用文献：《上皮钙通道TRPV6的失活模拟阻断》，发表于《Science Advances》2020年第6卷。