Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.
收藏Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
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Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state. Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide Authors: Johnson, E, McTigue, M, Cronin, C.N. Deposit date: 2018-12-21 Release date: 2019-05-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.966 Å) Cite: Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294, 2019
创建时间：
2018-12-21
