Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.
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Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state. Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide Authors: Johnson, E, McTigue, M, Cronin, C.N. Deposit date: 2018-12-21 Release date: 2019-05-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.966 Å) Cite: Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294, 2019
处于活性状态的双磷酸化HPK1激酶结构域与舒尼替尼（sunitinib）复合物的晶体结构。 描述符：丝裂原活化蛋白激酶激酶激酶激酶1（Mitogen-activated protein kinase kinase kinase kinase 1），N-[2-(二乙氨基)乙基]-5-[(Z)-(5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基]-2,4-二甲基-1H-吡咯-3-甲酰胺 作者：Johnson, E、McTigue, M、Cronin, C.N. 提交日期：2018-12-21，发布日期：2019-05-01，最后修改日期：2024-10-30 研究方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.966 Å 引用文献：《HPK1激酶结构域与舒尼替尼复合物的多种构象状态揭示伴随HPK1反式调控的结构变化》，《生物化学杂志》，294卷，2019年
