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Mtb-mediated host transcriptional reponse is strain-specific. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA145429
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CDC1551 induced more vigorous immune response in murine bone marrow derived macrophage (BMM). In contrast, in HN878-infected cells, host transcriptional response was delayed but lasted longer. HN878 induced more genes involved in host lipid metabolism than CDC1551 did. Overall design: Murine bone marrow derived macrophages were infected with M. tuberculosis CDC1551 or HN878 up to 24 h. Total RNA was processed for microarray and global gene expression was read.
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2011-08-30
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