Highly Enantioselective Fluorination of Unprotected 3‑Substituted Oxindoles: One-Step Synthesis of BMS 204352 (MaxiPost)
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https://figshare.com/articles/dataset/Highly_Enantioselective_Fluorination_of_Unprotected_3_Substituted_Oxindoles_One_Step_Synthesis_of_BMS_204352_MaxiPost_/2476498
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资源简介：
The catalytic enantioselective fluorination of N–H-free
3-substituted oxindoles was accomplished by a Sc(III)/N,N′-dioxide complex. Under mild reaction
conditions, a series of 3-aryl- and 3-alkyl-3-fluoro-2-oxindoles were
obtained in excellent yields (up to 98%) and enantioselectivities
(up to 99% ee) by using N-fluorobisbenzenesulfonimide
(NFSI) as the fluorination agent. MaxiPost was synthesized efficiently
in 81% yield with 96% ee.
创建时间：
2012-10-19
