PDK1 mutant bound to allosteric disulfide fragment activator JS30

PDK1 mutant bound to allosteric disulfide fragment activator JS30 Descriptor: 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, 3-phosphoinositide-dependent protein kinase 1, 4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-4-oxobutane-1-thiol, ... Authors: Sadowsky, J.D, Wells, J.A. Deposit date: 2010-09-13 Release date: 2011-03-23 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.1013 Å) Cite: Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc.Natl.Acad.Sci.USA, 108, 2011PDK1（3-磷酸肌醇依赖性蛋白激酶1，3-phosphoinositide-dependent protein kinase 1）突变体结合变构二硫键片段激活剂JS30。描述项：3-(1H-吲哚-3-基)-4-{1-[2-(1-甲基吡咯烷-2-基)乙基]-1H-吲哚-3-基}-1H-吡咯-2,5-二酮、3-磷酸肌醇依赖性蛋白激酶1、4-[4-(萘-1-基甲基)哌嗪-1-基]-4-氧代丁烷-1-硫醇等。作者：Sadowsky J.D.、Wells J.A.。存储日期：2010-09-13；发布日期：2011-03-23；最后修改日期：2024-10-09。检测方法：X射线衍射（分辨率2.1013 Å）。引用文献：《通过二硫键捕获技术从单一变构位点开启或关闭蛋白激酶活性》，《美国国家科学院院刊（Proc.Natl.Acad.Sci.USA）》，第108卷，2011年。