CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND Descriptor: 4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, CHLORIDE ION, GLYCEROL, ... Authors: Robinson, D.A, Brand, S, Fairlamb, A.H, Ferguson, M.A.J, Frearson, J.A, Wyatt, P.G. Deposit date: 2011-09-29 Release date: 2011-12-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012利什曼原虫（Leishmania major）N-肉豆蔻酰基转移酶（N-myristoyltransferase, NMT）结合肉豆蔻酰辅酶A（myristoyl-CoA）与吡唑磺酰胺配体的晶体结构 配体描述：4-溴-2,6-二氯-N-(1,3,5-三甲基-1H-吡唑-4-基)苯磺酰胺、氯离子、甘油…… 作者：Robinson, D.A.、Brand, S.、Fairlamb, A.H.、Ferguson, M.A.J.、Frearson, J.A.、Wyatt, P.G. 提交日期：2011-09-29 发布日期：2011-12-21 最后修改日期：2023-12-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.5埃（Å） 引用文献：《一类新型口服活性锥虫杀伤性N-肉豆蔻酰基转移酶抑制剂的发现》，《Journal of Medicinal Chemistry》，55卷，2012年