Association of snps of aif-1 gene with susceptibility to oral cancer in chinese population

Abstract To investigate the association between allograft inflammatory factor-1 (AIF-1) gene polymorphism and susceptibility to oral cancer in Chinese population. A case-control study was conducted to collect 400 cases of newly diagnosed oral cancer patients diagnosed by pathology from January 2015 to June 2019 and 400 cases of physical examination in the same period. Single nucleotide polymorphisms (SNPs) of the AIF-1 gene were detected using TaqMan probe technology. Unconditional logistic regression analysis was used to calculate the odd ratios (OR) and 95% confidence interval (CI) of the association between AIF-1 gene polymorphism and oral cancer susceptibility. GG genotypes reduced the risk of oral cancer in co-dominant models (OR = 0.499, 95% CI: 0.328-0.760, P = 0.001) and recessive models (OR = 0.496, 95% CI: 0.342-0.729, P < 0.001). There was no significant difference between the case group and the control group in the dominant model genotype (OR = 0.836, 95% CI: 0.623~1.121, P = 0.836). Conclusion AIF-1 gene rs2857595 gene SNPs can reduce the risk of oral cancer.