Additional file 1 of Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes

Additional file 1: Table S1. Sample information of the 2,642 PCAWG and 2,504 1KG in this study. Table S2. List of genes with pathogenic variant frequencies in Pan-cancer compared to controls. Table S3. Targeting cancer types for 6 significantly enriched cancer predisposition genes. Table S4. List of genes with pathogenic variant frequencies in single-cancer types compared to controls. Table S5. Functional annotation from GO and KEGG to 103 significantly enriched OMIM genes. Table S6. LOH events in 109 significantly enriched genes across 2,642 PCAWG samples. Table S7. 109 significantly enriched genes in cases with four features. Table S8. Two-hit preference and tissue expression across single-cancer type. Table S9. PAH dependent 220 putative metabolites quantified from the CE-TOFMS measurement.