Senescence progression in the normal human fibroblast, WI-38 cells induced with plasma membrane damage, calcium influx, DNA damage and telomere shortening.

To investigate the comparison of senescence progression in plasma membrane damage-, calcium influx-, DNA damage- and telomere shortening-induced senescence in the normal human fibroblast cells. Overall design: We performed gene expression profiling analysis using data obtained from RNA-seq of these four senescence inducers in human normal fibroblast cells at day 0, 1, 2, 3, 4, 6, 8 and 16 days after inducing with the senescence inducers.