Sniff Atlas v1.0: an open, breed-stratified catalogue of common canine coding variants with calibrated protein-language-model pathogenicity and an evidence-graded knowledge graph

An open, breed-stratified catalogue of the common and low-frequency coding-variant landscape of the domestic dog across 188 breeds: allele frequencies for 9,667,790 imputed variants (14,478 dogs, CanFam4) — ~6.7M common (MAF >= 5%) plus ~3.0M lower-frequency (MAF 1-5%) — with SnpEff annotation and three complementary deleteriousness layers (ESM2, Pangolin, Zoonomia 241-way phyloP; ESM2 calibrated at AUC 0.935 vs OMIA), an evidence-graded Biolink knowledge graph, and a bcftools-queryable sites VCF. Scope: MAF >= 1% (the CanVAS imputation floor; sub-1% variants are out of scope). Independently validated against the NHGRI (National Human Genome Research Institute) 722 directly-sequenced whole-genome catalogue (Plassais et al. 2019). Derived from CanVAS (doi:10.5281/zenodo.19186944, Brundage 2026); raw genotypes not redistributed. See README/VALIDATION/CITATIONS inside the archive. Aggregate data only (no individual dog identifiers); OMIA-derived clinical layer held for v1.1.