Epidermal APCs trigger IFN-γ production by CD8+ TEFF cells.
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(A,B) Analysis of IFN-γ+ in vitro activated gBT-I (A,B) and gDT-II (B) TEFF cells cultured (as in Figure 5) with increasing numbers of CD45.2− and CD45.2+ APCs sorted from epidermal sheets (pooled from 20 mice) 4 days after HSV-1 skin infection. Data representative (A) or pooled from 2–3 experiments (B). (C,D) Analysis of IFN-γ+ in vitro activated gBT-I cells cultured with sorted APCs from epidermal sheets (pooled from 20 mice) 4 days after infection. APC numbers were 5×104 for keratinocytes (KC), CD11c+ and residual CD45.2+CD11c−Vγ3− (CD45.2+) cells; 3×104 for DETCs. Data representative (C) or pooled from 2 experiments (D). **, P
创建时间：
2016-02-24
