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Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP345026
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The goal of this study is to compare the different biological functions between nuclear (ICD)-TYRO3- and kinase dead (KD)-TYRO3-overexpressed cells by BRD3 occupancy profiling. We revel that ICD-TYRO3-overexpressed cell were particularly enriched in negatively regulate cell death, regulation of cell cycle, regulation of vascular permeability, positively regulation of EMT, cell-cell adhesion, and regulation of phosphorylation. Overall design: ChIP-seq profiles of nuclear TYRO3 or kinase-dead TYRO3 overexpressing HCT116 cells
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2025-02-12
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