Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

The goal of this study is to compare the different biological functions between nuclear (ICD)-TYRO3- and kinase dead (KD)-TYRO3-overexpressed cells by BRD3 occupancy profiling. We revel that ICD-TYRO3-overexpressed cell were particularly enriched in negatively regulate cell death, regulation of cell cycle, regulation of vascular permeability, positively regulation of EMT, cell-cell adhesion, and regulation of phosphorylation. Overall design: ChIP-seq profiles of nuclear TYRO3 or kinase-dead TYRO3 overexpressing HCT116 cells