Effect of Sumo2 deletion on gene expression in the mouse brain

Mounting evidence indicates that small ubiquitin-like modifier (SUMO) conjugation regulates a wide range of neuronal functions and participates in learning and memory processes. Since many SUMO targets are transcription factors as well as other nuclear proteins modulating gene expression and SUMO2 is the predominant SUMO isoform, we aimed to identify how SUMO2 regulates gene expression in the brain in order to better understand the role of SUMOylation in the brain function. In this study, we performed RNA-Seq analysis on hippocampus from SUMO2 conditional knockout mice. Compare gene expression between control (Sumo2 f/f) mice and SUMO2 conditional knockout (SUMO2-cKO; Sumo2 f/f; Emx1-Cre) mice.