Mechanisms and Disease Associations of Oxidative Stress-Mediated Brain-Bone Axis Dysregulation: A Knowledge Mapping and Trend Analysis Based on Bibliometrics

Background: Oxidative stress, characterized by the systemic imbalance between reactive oxygen species and antioxidant defenses, is increasingly recognized as a central pathological nexus driving the dysregulation of the brain-bone axis. Despite the accumulation of empirical evidence, a systematic characterization of the field's intellectual structure and thematic progression remains absent. This study employs a multi-database bibliometric approach to map the research landscape of oxidative stress-mediated neuro-skeletal crosstalk and identify emerging research frontiers.Methods: A systematic search was performed across the Web of Science Core Collection, Scopus, and PubMed databases from their inception to April 30, 2025. Following a rigorous screening process based on predefined criteria, 717 relevant publications were included. Bibliometric mapping and network analyses were conducted using CiteSpace, VOSviewer, and the Bibliometrix R-package to evaluate collaboration patterns, co-citation structures, and keyword evolution.