A BRCA1 interacting lncRNA regulates homologous recombination
收藏NIAID Data Ecosystem2026-03-08 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
应用场景：
创建时间：
2015-08-25
相关数据集
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination (ChIP-seq). 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination (ChIP-seq)
53BP1 activity drives genome instability and embryonic lethality in BRCA1-deficient cells by inhibiting homologous recombination (HR).53BP1’s anti-recombinogenic functions require phosphorylation-depe
NIAID Data Ecosystem60
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs
DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair. The Mediator of DNA d
NIAID Data Ecosystem40
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
DNA-dependent protein kinase (DNA-PK), composed of Ku70, Ku80, and the catalytic subunit (DNA-PKcs), is involved in repairing double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ). Certain p
PubMed Central2002-03-19 更新30
The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining
DNA damage activates the cell cycle checkpoint to regulate cell cycle progression. The checkpoint clamp (Rad9-Hus1-Rad1 complex) is recruited to damage sites, and is required for checkpoint activation
NIAID Data Ecosystem40
Phosphoproteomic Datasets for Mec1/ATR Signaling Upon Hyper-Resection (TMT Supplement)
The Mec1/ATR kinase is crucial for genome maintenance, although the mechanisms by which it controls DNA repair pathways remain elusive. Here we uncovered a role for Mec1/ATR in controlling homologous
NIAID Data Ecosystem30
