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Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis. Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis

NIAID Data Ecosystem2026-03-08 收录

Dnmt3b靶标甲基化

白血病发病机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA290163 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2015-07-17

造血干细胞调控

白血病发病机制

Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how

NIAID Data Ecosystem120

Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [ChIP-seq]

白血病发病机制

细胞转录调控

Normal hematopoiesis is regulated by various cytokines via the JAK-STAT signaling pathway. Gene deletion studies in mice have demonstrated the crucial role of STAT5B in the proliferation, differentiat

NIAID Data Ecosystem50

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]

白血病发病机制

表观遗传调控

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA

NIAID Data Ecosystem30

Hematopoietic stem cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia [RNASeq_Cdx2_secondaryAML]

白血病发病机制

造血干细胞

The caudal-related homeobox transcription factor CDX2 is ectopically expressed in the majority of patients with acute myeloid leukemia (AML). We generated an inducible transgenic mouse model whereby C

NIAID Data Ecosystem70

ChIP-seq BigWig signal tracks for genome-wide chromatin profiling in CD34+ PB-HSPCs and

基因组学分析

白血病发病机制

These bigWig files contain normalized ChIP-seq signal tracks generated from CD34+ PB-HSPCs and in vitro differentiated megakaryocytes and monocytes. The data represent genome-wide binding profiles of

NIAID Data Ecosystem40

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis. Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis

资源简介：

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