Fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and deteriorates liver damage in PBC mouse model

The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) have not been fully understood. In this work, the effect of gut microbiota of PBC patients on both healthy mice and mice of PBC model was explored by fecal microbiota transplantation (FMT); then, the potential mechanism of gut microbiota affecting PBC was further investigated by comparing alterations in liver gene expression and pathway caused by FMT with those in PBC patients.