BIOGRID CURATED DATA FOR AIP1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for AIP1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress

AIP1（酿酒酵母S288c）的蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）整理；定义：肌动蛋白皮质斑成分；与肌动蛋白去聚合因子cofilin相互作用；抑制带有cofilin的衰老ADP-肌动蛋白丝的延长，以维持高水平的组装能力肌动蛋白种类；限制cofilin定位于皮质斑内所必需；推测为细胞分裂的调节因子；含有WD重复序列；在DNA复制压力下，蛋白质含量增加并从细胞质重新定位到质膜。