Crystal Structure of EgtUC binding domain mutant T274G bound to L-Ergothioneine from S. pneumoniae

Crystal Structure of EgtUC binding domain mutant T274G bound to L-Ergothioneine from S. pneumoniae Descriptor: Ergothioneine transporter EgtUC, trimethyl-[(2S)-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azanium Authors: Legg, K.A, Gonzalez-Gutierrez, G, Giedroc, D.P. Deposit date: 2024-11-21 Release date: 2025-11-26 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: CH•••S hydrogen bonds drive molecular recognition of ergothioneine by the microbial transporter. Sci Adv, 12, 2026肺炎链球菌（S. pneumoniae）来源的、结合L-麦角硫因（L-Ergothioneine）的EgtUC结合结构域突变体T274G的晶体结构 描述：麦角硫因转运蛋白EgtUC，配体为三甲基-[(2S)-1-羧基-3-(2-硫代-1,3-二氢咪唑-4-基)丙-2-基]铵 作者：Legg, K.A.、Gonzalez-Gutierrez, G.、Giedroc, D.P. 提交日期：2024-11-21 发布日期：2025-11-26 最后修改日期：2026-04-15 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.95 Å 引用文献：CH•••S氢键驱动微生物转运蛋白对麦角硫因的分子识别. 《科学进展》（Sci Adv）, 12, 2026