Changes of hemodynamic and laboratory parameters at 15 and 60 min following start of transfusion.

Data are depicted as mean±standard deviation. P-values (Welch’s t-Test) indicate differences among patients receiving fresh and standard-issue PRBCs. Statistically significant data are printed bold. Abbreviations: Δ15, change in parameter during transfusion; Δ60, change in parameter within the first 60 minutes after starting transfusion; CI, cardiac index; Hb, hemoglobin; MIF, macrophage migration inhibitory factor; PAP, pulmonary arterial pressure; PRBCs, packed red blood cells; PVRI, pulmonary vascular resistance index; SDC, syndecan-1; SVRI, systemic vascular resistance index; MAP, mean arterial pressure; CI, cardiac index.