Molecular and Structural Characterisation of Components of the Flagellar System in Helicobacter pylori

This thesis, titled "Molecular and Structural Characterisation of Components of the Flagellar System in Helicobacter pylori," focuses on unraveling the molecular composition, function and structural details of the unique flagellar system in H. pylori. The study characterizes known scaffold proteins PflA and PflB, identifies novel components using co-immunoprecipitation and mass spectrometry, and analyzes the crystal structures of the MotB plug domain and the Csep1p protein from Campylobacter concisus. These insights enhance our understanding of the flagellar motor's high torque generation and adaptive mechanisms, contributing to the broader knowledge of bacterial motility and pathogenesis.