Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

A series
of platinum­(II) complexes, characteristic of chiral trans-bicyclo­[2.2.2]­octane-7,8-diamine as ligand possessing dicyclic steric
hindrance, were designed and synthesized. Biological evaluation showed
that almost all complexes had cytotoxic activity against the tested
cancer cell lines, among which most of chiral (R,R)-enantiomeres had stronger cytotoxicity than their (S,S)-counterparts, and 2a,
[trans-bicyclo­[2.2.2]­octane-7R,8R-diamine]­(oxalato-O,O′)­platinum­(II), is the most effective agent. Significantly,
its counterpart, 2b, was much more sensitive to cisplatin
resistant SGC7901/CDDP cancer cell line at a higher degree than 2a. Docking study and agarose gel electrophoresis revealed
that the interaction of 2a with DNA was similar to that
of oxaliplatin. Western blot analysis demonstrated that 2a could induce a better effect than cisplatin on a mitochondrial-dependent
apoptosis pathway. Kinetic study indicated that the dicyclic ligand
can accelerate the reaction rate of the complex.